A. Sherif El-Gizawy, PhD, and Raja Gopaldas, MD

Principal Investigators

A. Sherif El-Gizawy, PhD

Department of Mechanical and Aerospace Engineering

Raja Gopaldas, MD

Department of Surgery

A. Sherif El-Gizawy, PhD, (left)
and Raja Gopaldas, MD

An embolic protection device to aid in transcatheter aortic-valve implantation and prevent neurological dysfunction

There are approximately 250,000 aortic valve replacement procedures globally per year, with 90,000 of the procedures being done in the United States. Open heart surgery is the current standard of care for aortic valve replacement, but 40% of patients cannot tolerate open heart surgery due to underlying health related issues or age. Within the last two years, the minimally invasive TAVI procedure has become available to these high risk patients. However, 22% of TAVI recipients manifest acute cerebral diffusion abnormalities or intra-operative strokes.

In this project, the PIs have developed a device that creates a protective barrier with-in the aorta preventing embolic debris from entering brain vessels. This technology has been licensed to Cardioptimus. Active fundraising is proceeding to continue development of the