Carole McArthur, MD, PhD and Shubhra Gangopadhyay, PhD

Principal Investigators

Carole McArthur, MD, PhD

Department of Oral and Craniofacial Sciences;
University of Missouri-Kansas City

Shubhra Gangopadhyay, PhD

Department of Electrical and Computer Engineering

Carole McArthur, MD, PhD, (left)
and Subhra Gangopadhyay, PhD

Plasmonic grating point-of-care system for detection of TB

The World Health Organization (WHO) estimates that in 2013 Mycobacterium tuberculosis (TB) represented more than half of the $2 billion medical diagnostic market. Additionally, WHO states that there are 8.6 million cases of TB diagnosed each year, while 1.3 million people die of TB each year. The current gold standard for TB testing is either chest radiography or plate culture, which is then followed by drug sensitivity screening. Chest radiography is available in many developing nations, but is not practical in resource-limited settings. The more popular technique in developing nations is plate culture, which often takes weeks before results are known.

A rapid, low cost TB test that can be performed in low resource settings is a global health priority. The principal investigators have recently developed an inexpensive soft lithographic process for producing nano-ordered plasmonic gratings with extraordinary electromagnetic field enhancements that are ideally suited for detection of TB infection in low resource settings. These novel nano-gratings can be used to perform antigen-antibody assays such as interferon gamma (IFNγ) test for TB infection using common fluorescence detection technology and are potentially adaptable to multiplexing and drug resistance screening.

This new diagnostic platform technology has broad clinical applications in both high and low resource settings.

Funded in 2014