Gary Yao and Mark Hunter

Principal Investigators

Gary Yao, PhD

Department of Bioengineering

Mark Hunter, MD

Department of Gynecologic Oncology

OPT-Enhanced Colposcopy: 3D Detection of Precancerous and Cancerous Lesions for Image-Guided Biopsy

Each year, approximately 2 million women in the United States are referred for colposcopy after positive Pap smear/HRV screening results, and over a half-million women worldwide are diagnosed with cervical cancer. Fortunately, when correctly identified using colposcopy, precancerous lesions (cervical intraepithelial neoplasia or “CIN”) are fully treatable. However, current video-based colposcopy is subjective and requires tissue destruction. Because tissue samples must be sent to the pathology lab for analysis, it has a long lead time for diagnosis. The proposed OPT-Enhanced Colposcopy is a new imaging system based on optical polarization tractography (OPT) technology that makes it possible to accurately and objectively identify and stage CIN, as well as invasive cancerous lesions, during the colposcopy procedure. OPT enables precise 3D imaging of subsurface cellular morphological changes in a living organism. These changes are histology‐comparable markers of precancerous lesions and invasive cancer. OPT-Enhanced Colposcopy could potentially allow clinicians to precisely detect lesions, perform image‐guided therapy and verify treatment outcomes all in a single colposcopy session.